PT  - JOURNAL ARTICLE
AU  - Andras Bikov
AU  - Noemi Eszes
AU  - Aniko Bohacs
AU  - Aron Cseh
AU  - Gergely Toldi
AU  - Veronika Muller
AU  - Janos Rigo
AU  - Barna Vasarhelyi
AU  - Gyorgy Losonczy
AU  - Lilla Tamasi
AU  - Ildiko Horvath
TI  - Relationship between circulating Th2 prevalence and asthma control in pregnant asthmatics
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p4023
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p4023.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p4023.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: Asthma is one of the most common diseases complicating pregnancy and a risk factor for several maternal and fetal complications. It was previously shown that altered systemic inflammation present in pregnant asthmatics may contribute to the outcome of the pregnancy; however less has been known about the relationship between circulating T cell profiles and clinical characteristics of asthma in pregnant patients.Aim: The aim of this study was to assess the relationship between various T cell profiles and clinical variables in asthma during gestation, including lung function, exhaled nitric oxide, and asthma control.Methods: The prevalence of Th1, Th2, and Treg lymphocyte subsets was identified by cell surface markers and intracellular FoxP3 staining in 22 pregnant women in the second or third trimester suffering from persistent allergic asthma. FENO, Asthma Control Test (ACT) total score and lung function were also evaluated.Results: A significant negative relationship was observed between Th2 cell prevalence and ACT total scores (r=-0.48, p=0.03), while no relationship was found between Th2 prevalence and FENO or lung function parameters. However, none of the other T cell subsets were correlated to any of the clinical characteristics (FENO, lung function, or ACT; p>0.05).Conclusions: The level of asthma control related to blood Th2 cell prevalence suggests a direct relationship between symptoms and cellular mechanisms of asthma in pregnant patients.The study was supported by OTKA 68808.