TY - JOUR T1 - Relationship between circulating Th2 prevalence and asthma control in pregnant asthmatics JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4023 AU - Andras Bikov AU - Noemi Eszes AU - Aniko Bohacs AU - Aron Cseh AU - Gergely Toldi AU - Veronika Muller AU - Janos Rigo AU - Barna Vasarhelyi AU - Gyorgy Losonczy AU - Lilla Tamasi AU - Ildiko Horvath Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4023.abstract N2 - Introduction: Asthma is one of the most common diseases complicating pregnancy and a risk factor for several maternal and fetal complications. It was previously shown that altered systemic inflammation present in pregnant asthmatics may contribute to the outcome of the pregnancy; however less has been known about the relationship between circulating T cell profiles and clinical characteristics of asthma in pregnant patients.Aim: The aim of this study was to assess the relationship between various T cell profiles and clinical variables in asthma during gestation, including lung function, exhaled nitric oxide, and asthma control.Methods: The prevalence of Th1, Th2, and Treg lymphocyte subsets was identified by cell surface markers and intracellular FoxP3 staining in 22 pregnant women in the second or third trimester suffering from persistent allergic asthma. FENO, Asthma Control Test (ACT) total score and lung function were also evaluated.Results: A significant negative relationship was observed between Th2 cell prevalence and ACT total scores (r=-0.48, p=0.03), while no relationship was found between Th2 prevalence and FENO or lung function parameters. However, none of the other T cell subsets were correlated to any of the clinical characteristics (FENO, lung function, or ACT; p>0.05).Conclusions: The level of asthma control related to blood Th2 cell prevalence suggests a direct relationship between symptoms and cellular mechanisms of asthma in pregnant patients.The study was supported by OTKA 68808. ER -