RT Journal Article
SR Electronic
T1 Are upper airways resistance syndrome and obstructive sleep apnea a side-effect of oral cancer therapy?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3468
VO 38
IS Suppl 55
A1 S.P. Tandon
A1 A. Khutarkar
A1 S. Ansari
A1 M. Khale
A1 S.K. Rajan
A1 J. Deodhar
A1 J.P. Agarwal
A1 P. Chaturvedi
A1 P. Pai
A1 D. Chaukar
A1 R. Havaldar
A1 S. Laskar
A1 P. Yadav
A1 A.K. D'Cruz
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3468.abstract
AB Background: Reconstructive surgery and radiotherapy cause changes in airway calibre and tone which may lead to Upper Airways Resistance Syndrome (UARS) and Obstructive Sleep Apnea (OSA). We aimed to study the prevalence of UARS and OSA in treated Oral Cancer patients.Methodology: 78 patients (69 males, 9 females, mean age 49 years) treated for Oral Cancer were administered the Epworth Sleepiness Scale (ESS). Patients' perception of sleep quality (SLq) and mental health status were noted from Mental Health and Quality of Life Questionnaires (GHQ28, EORTC QLQ-C30 (V03), QLQ-H&N35) and all underwent Polysomnography. They were categorised on the basis of Respiratory Disturbance Index (RDI) {i.e.Apnea-Hypopnea Index (AHI) with Respiratory Effort Related Arousals (RERAs)} into Normal (RDI<5/h), UARS (RDI 5-15/h), OSA (RDI>15/h) and Sleep Disordered Breathing (SDB) where (SDB=UARS+OSA: RDI>5/h).Results: 66 patients underwent surgery with adjuvant (chemo)radiation and remaining 12 (chemo)radiation.SDB defined by RDI was present in 70.5% as compared to 29.5% defined by AHI. 48.7% had UARS and 21.8% had OSA.SLq was significantly associated with high GHQ28 scores (p=0.002) and SDB (p=0.04).Conclusions: Upper Airways Resistance Syndrome and Obstructive Sleep Apnea are a common yet unrecognised problem in treated Oral Cancer patients.Apnea-Hypopnea Index underestimated SDB,UARS and OSA significantly (29.5%,24.4% and 5.1% respectively)with a higher prevalence (70.5%,48.7% and 21.8%) as per the Respiratory Disturbance Index which included Respiratory Effort Related Arousals.Poor mental health is associated with disturbed sleep in these patients,but Sleep Disordered Breathing may also be a contributing factor.