@article {Thursfield4660, author = {Rebecca Thursfield and Andrew Bush and Alex Adams and Andrew G. Nicholson and Katy Holden}, title = {What is the significance of aspergillus fumigatus in BAL in children with cystic fibrosis}, volume = {38}, number = {Suppl 55}, elocation-id = {4660}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Background: Aspergilllus fumigatus (AF) is frequently found in the airways of children with cystic fibrosis (CF) and recent evidence suggests this may be clinically important. (Chest 2006;130:222, Ped Pulm 2007;42:785)Aims: In this retrospective study, we hypothesised that children with CF who have AF seen on direct staining of bronchoalveolar lavage (BAL) will have a worse clinical state than both those who only culture AF (positive controls) and those with no isolation (negative controls). Primary outcome was FEV1; secondary outcomes included BMI, IgE, IV antibiotics, steroids and antifungals.Results: In the year prior to bronchoscopy (FOB), the groups were similar in terms of weight centile, IV antibiotics received and FEV1. One year post FOB, the groups with AF in their BAL, on cytology or microscopy, had a lower FEV1 despite receiving more IV antibiotics and more antifungal therapy.View this table:Patient groupsView this table:Lung functionThe group without AF had a greater increase in FEV1.Conclusion: The results add to the growing evidence that AF in the airways of children with CF is associated with a worse clinical state, whether identified on direct smear or culture.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/4660}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }