@article {Latorrep305, author = {Irene Latorre and Sonia Minguez and Marta Vilavella and Jessica Diez and Jose Manuel Carrascosa and Cristina Prat and Lourdes Mateo and Eugeni Domenech and Vicente Ausina and Carlos Ferrandiz and Jose Dominguez}, title = {Detection of IFN-γ responses for diagnosis of tuberculosis infection in chronic inflammatory disease patients}, volume = {38}, number = {Suppl 55}, elocation-id = {p305}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Objective: Determine IFN-γ responses for latent tuberculosis infection (LTBI) diagnosis in chronic inflammatory disease patients.Material and methods: 89 chronic inflammatory disease patients were classified in 3 groups. Group 1: 53 patients with rheumatic diseases scheduled for anti-TNF-α treatment. Group 2: 23 psoriasis patients, 39.1\% were receiving biologic treatments, and 43.5\% classic systemic treatments. Group 3: 13 patients with Crohn disease, treated with immunosuppressors. TST was done in all cases. We determined IFN-γ production with Quantiferon-TB Gold In Tube (QFN) and T-SPOT.TB (TS.TB).Results: Group 1: TS.TB, QFN and TST were positive in 20.8\%, 17\% and 13.2\% respectively. We obtained 4 QFN indeterminate results (7.5\%) and 2 for TS.TB (3.8\%), in all cases TST was negative and corresponded with patients receiving corticoids. Concordance (κ) between TS.TB and QFN was 0.562. Group 2: TS.TB and QFN were positive in 17.14\% of the cases. In contrast, TST was positive in 21.74\%. Five patients were documented with a previous positive TST. Therefore, when we analyzed patients with IFN-γ assays and TST performed simultaneously, TS.TB and QFN were positive in 5.6\% and TST negative in all cases. Concordance between TS.TB and QFN was 100\% Group 3: The three assays were negative in all cases. We observed one TS.TB indeterminate result (7.7\%) and 2 for QFN (15.4\%), corresponding with patients receiving azathioprine.Conclusions: Concordance between both IFN-γ assays was good.Indeterminate results were higher in those patients with Crohn disease.IFN-γ assays, in combination with TST, are useful for the diagnosis of LTBI in patients with inflammatory diseases.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p305}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }