RT Journal Article SR Electronic T1 Rapid cytological analysis of endobronchial ultrasound-guided aspirates in sarcoidosis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1302 OP 1308 DO 10.1183/09031936.00128312 VO 42 IS 5 A1 Marshall L. Plit A1 Adrian P. Havryk A1 Alan Hodgson A1 Daniel James A1 Andrew Field A1 Sonia Carbone A1 Allan R. Glanville A1 Farzad Bashirzadeh A1 Anna M. Chay A1 Justin Hundloe A1 Rebecca Pearson A1 David Fielding YR 2013 UL http://erj.ersjournals.com/content/42/5/1302.abstract AB Rapid on-site evaluation (ROSE) of endobronchial ultrasound-guided transbronchial needle aspirates (EBUS-TBNA) has not been compared to final detailed cytological analysis in patients with suspected sarcoidosis. To assess the diagnostic accuracy of EBUS-TBNA with ROSE in patients with suspected sarcoidosis, a prospective two-centre study performed EBUS-TBNA with ROSE of cellular material followed by transbronchial lung biopsy (TBLB) and endobronchial biopsy (EBB). The diagnostic accuracy of EBUS-TBNA with ROSE was compared to the final cytological assessment and to TBLB and EBB. Analysis confirmed 49 out of 60 cases of sarcoidosis. ROSE sensitivity was 87.8% (specificity 91%, positive predictive value 97.7%). ROSE slide interpretation in combination with the final fixed slide and cell block preparations had a sensitivity of 91.8% (specificity 100%, positive predictive value 100%). 67% of patients were confirmed as having sarcoidosis on TBLB and 29% on EBB. Interobserver agreement between cytotechnologists and pathologists was very good (κ=0.91, 95% CI 0.80–1.0 and κ=0.91, 95% CI 0.79–1.0, respectively). EBUS-TBNA with ROSE has high diagnostic accuracy and interobserver agreement and informs the bronchoscopist in theatre whether additional diagnostic procedures need to be undertaken. EBUS-TBNA with ROSE should therefore be considered as the first-line investigation of sarcoidosis. Rapid on-site evaluation of EBUS-TBNA should be first-line investigation in sarcoidosis http://ow.ly/nT9Mx