PT  - JOURNAL ARTICLE
AU  - Hans Scheers
AU  - Tim Nawrot
AU  - Stijn Verleden
AU  - Rachel Geenens
AU  - Peter Hoet
AU  - Frans Fierens
AU  - Verbeken Erik
AU  - Ben Nemery
AU  - Dirk Van Raemdonck
AU  - Geert Verleden
AU  - Bart Vanaudenaerde
TI  - Short-term variation in air pollution triggers acute rejection after lung transplantation
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1767
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1767.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1767.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Epidemiological studies demonstrated that fine particulate air pollution (PM) can trigger adverse health outcomes. Recently, we demonstrated that chronic exposure to air pollution is associated with increased risk of chronic rejection and mortality after lung transplantation. In the present study, we investigated whether short-term elevations in ambient PM10 increased the risk of acute rejection after lung transplantation.All transbronchial biopsies from a routine follow-up of 355 transplanted patients at the University Hospital Leuven were included. Acute perivascular and peribronchial rejection was scored and% BAL neutrophils and serum CRP were assessed. We used land use data to calculate the background level of PM10 for each participant's home address using a kriging interpolation method. We estimated% BAL neutrophils, serum CRP and the risk of acute rejection in relation with outdoor PM10 concentrations on the day of tissue sampling and up to five days before. The model was adjusted for covariates such as age, sex, post-operative day (POD) and daily temperature.The odds of acute rejection increased by 30% (95% CI: 4-61%) for each 10 μg/m3 increment in ambient PM10 concentration three days before the day of biopsy (lag day 3). Log-transformed neutrophils and serum CRP were significantly related to PM10 as well. For each 10 μg/m3 increment in ambient PM10 concentration on lag day 2,% BAL neutrophils increased by a factor 1.09 (95%CI 1.01-1.18) and serum CRP increased by a factor 1.10 (95%CI 1.02-1.18).We showed that short-term variation in ambient air pollution acts as a trigger of acute rejection after lung transplantation, probably mediated by a pro-inflammatory response.