PT - JOURNAL ARTICLE AU - Edvardsen, Anne AU - Ryg, Morten AU - Akerø, Aina AU - Christensen, Carl Christian AU - Skjønsberg, Ole H. TI - COPD and air travel: does hypoxia-altitude simulation testing predict in-flight respiratory symptoms? AID - 10.1183/09031936.00157112 DP - 2013 Nov 01 TA - European Respiratory Journal PG - 1216--1223 VI - 42 IP - 5 4099 - http://erj.ersjournals.com/content/42/5/1216.short 4100 - http://erj.ersjournals.com/content/42/5/1216.full SO - Eur Respir J2013 Nov 01; 42 AB - The reduced pressure in an aircraft cabin may cause significant hypoxaemia and respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD). The current study evaluated whether there is a relationship between hypoxaemia obtained during hypoxia-altitude simulation testing (HAST), simulating an altitude of 2438 m, and the reporting of respiratory symptoms during air travel. 82 patients with moderate to very severe COPD answered an air travel questionnaire. Arterial oxygen tensions during HAST (PaO2HAST) in subjects with and without in-flight respiratory symptoms were compared. The same questionnaire was answered within 1 year after the HAST. Mean±sd PaO2HAST was 6.3±0.6 kPa and 62 (76%) of the patients had PaO2HAST <6.6 kPa. 38 (46%) patients had experienced respiratory symptoms during air travel. There was no difference in PaO2HAST in those with and those without in-flight respiratory symptoms (6.3±0.7 kPa versus 6.3±0.6 kPa, respectively; p=0.926). 54 (66%) patients travelled by air after the HAST, and patients equipped with supplemental oxygen (n=23, 43%) reported less respiratory symptoms when flying with than those without such treatment (four (17%) versus 11 (48%) patients; p=0.039). In conclusion, no difference in PaO2HAST was found between COPD patients with and without respiratory symptoms during air travel. Hypoxia-altitude simulation testing does not predict in-flight respiratory symptoms in COPD patients http://ow.ly/nUCtF