RT Journal Article
SR Electronic
T1 Reduced neonatal lung function and wheezing illnesses during the first 5 years of life
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 107
OP 115
DO 10.1183/09031936.00214711
VO 42
IS 1
A1 Anne C. van der Gugten
A1 Cuno S.P.M. Uiterwaal
A1 Nienke van Putte-Katier
A1 Marije Koopman
A1 Theo J.M. Verheij
A1 Cornelis K. van der Ent
YR 2013
UL http://erj.ersjournals.com/content/42/1/107.abstract
AB Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance (Rrs) and compliance (Crs) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort. SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file. 549 infants had a successful SOT measurement and complete medical records. Every kPa·L−1·s−1 increase in Rrs was associated with 10% more consultations in the first 3 years of life. Every 10 mL·kPa−1 increase in Crs was associated with a 14% reduction in consultations in the first 3 years of life, 27% in the fourth to fifth years of life, and a lower probability of having asthma at the age of 5 years (OR 0.66). Children with late-onset or persistent wheezing had significant lower Crs values than their peers. An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma.