PT  - JOURNAL ARTICLE
AU  - Ebru Sulu
AU  - Makbule Ozlem Akbay
AU  - Esra Akkutuk
AU  - Ferda Aksoy
AU  - Guven Bektemur
AU  - Huriye Berk Takir
AU  - Adnan Yilmaz
TI  - Castleman's disease presenting as a pleural mass in the thoracic cavity
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2426
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2426.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2426.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - A 61-year-old Turkish woman presented with a 10-month history of chest pain. Chest radiography showed nonhomogeneous density obliterating left costophrenic sinus. Chest computed tomography revealed a heterogeneous mass measuring 40×60-mm with calcification and necrosis at left posterolateral hemithorax. Bronchoscopy was normal. CT-guided cutting needle biopsy was nondiagnostic. Magnetic resonance imaging revealed 40×60-mm sized mass having central calcification and necrosis at left posterolateral hemithorax. On thoracotomy, an extraparenchymal mass destructing the ribs was determined. Mass excision and partial chest wall resection were performed. Grossly, the mass was pinkish yellow in colour and had a rubbery consistency with fibrous bands. Microscopic examination was characterized by germinal follicules surrounded by concentric layers of small lymphocytes and proliferative hyalinized vascular stroma in parafollicular area. All tumor cells stain positively with CD45, and negatively with pancytokeratin, while the follicular cells stain positively with CD20, and the parafollicular cells stain positively with CD3, immunohistochemically. The final diagnosis was angiofollicular lymph node hyperplasia (Castleman's disease) hyaline- vascular type in pleura.