RT Journal Article
SR Electronic
T1 Prevalence and prognosis of COPD in critically ill patients between 1998 and 2008
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 792
OP 799
DO 10.1183/09031936.00226411
VO 41
IS 4
A1 Georg-Christian Funk
A1 Peter Bauer
A1 Otto Chris Burghuber
A1 Andreas Fazekas
A1 Sylvia Hartl
A1 Helene Hochrieser
A1 Rene Schmutz
A1 Philipp Metnitz
YR 2013
UL http://erj.ersjournals.com/content/41/4/792.abstract
AB The epidemiology of chronic obstructive pulmonary disease (COPD) in critically ill patients is largely unknown. The aims of the study were: 1) to determine whether COPD, either as the cause of intensive care unit (ICU) admission or as a comorbid condition, is an independent risk factor for increased morbidity and mortality; and 2) to investigate time trends in proportion and outcome of acute respiratory failure in patients with COPD admitted to ICUs. Prospectively recorded data from 194 453 adults consecutively admitted to 87 Austrian ICUs over a period of 11 years (1998–2008) were retrospectively analysed. COPD was present in 8.6% of all patients. The risk-adjusted mortality of patients with COPD was higher than in patients without COPD. The presence of COPD was an independent risk factor for increased mortality and was associated with prolonged mechanical ventilation and prolonged weaning. During the course of the 11 years, the proportion of acute respiratory failure due to COPD increased by about two-thirds, and the use of noninvasive ventilation within the COPD cohort more than doubled. Simultaneously, the risk-adjusted mortality of patients with COPD improved. In critically ill patients, the presence of COPD is increasing and is an independent risk factor for mortality and morbidity.