PT  - JOURNAL ARTICLE
AU  - Lucia H. Rijssenbeek-Nouwens
AU  - Karin B. Fieten
AU  - Adriaan O. Bron
AU  - Simone Hashimoto
AU  - Elisabeth H. Bel
AU  - Els J. Weersink
TI  - High-altitude treatment in atopic and nonatopic patients with severe asthma
AID  - 10.1183/09031936.00195211
DP  - 2012 Dec 01
TA  - European Respiratory Journal
PG  - 1374--1380
VI  - 40
IP  - 6
4099  - http://erj.ersjournals.com/content/40/6/1374.short
4100  - http://erj.ersjournals.com/content/40/6/1374.full
SO  - Eur Respir J2012 Dec 01; 40
AB  - The beneficial effects of high-altitude treatment in asthma have been attributed to allergen avoidance. Recent evidence shows that this treatment also improves airway inflammation in nonallergic patients. We hypothesised that high-altitude treatment is clinically equally effective in patients with severe refractory asthma, with or without allergic sensitisation. In a prospective observational cohort study, 137 adults with severe refractory asthma (92 with allergic sensitisation), referred for high-altitude (1,600 m) treatment in Davos, Switzerland, were consecutively included. We measured asthma control (Asthma Control Questionnaire (ACQ)), asthma-related quality of life (Asthma-Related Quality of Life Questionnaire (AQLQ)), sino-nasal symptoms (Sino-Nasal Outcome Test (SNOT-20)), medication requirement, postbronchodilator (post-BD) forced expiratory volume in 1 s (FEV1), 6-min walking distance (6MWD), total immunoglobulin (Ig)E, blood eosinophils and exhaled nitric oxide fraction (FeNO) at admission and after 12 weeks. Sensitised and nonsensitised patients showed similar improvements in ACQ (-1.4 and -1.5, respectively; p=0.79), AQLQ (1.6 and 1.5, respectively; p=0.94), SNOT-20 (-0.7 and -0.5, respectively; p=0.18), post-BD FEV1 (6.1% and 5.8% pred, respectively; p=0.87), 6MWD (+125 m and +147 m, respectively; p=0.43) and oral steroids (40% versus 44%, respectively; p=0.51). Sensitised patients showed a larger decrease in total IgE, blood eosinophils and FeNO. High-altitude treatment improves clinical and functional parameters, and decreases oral corticosteroid requirement in patients with severe refractory asthma, irrespective of allergic sensitisation.