PT - JOURNAL ARTICLE AU - David A. McAllister AU - John D. Maclay AU - Nicholas L. Mills AU - Andrew Leitch AU - Philip Reid AU - Ross Carruthers AU - Jennifer O’Connor AU - Lawrence McAlpine AU - George Chalmers AU - David E. Newby AU - Elaine Clark AU - Peter W. Macfarlane AU - William MacNee TI - Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD AID - 10.1183/09031936.00124811 DP - 2012 May 01 TA - European Respiratory Journal PG - 1097--1103 VI - 39 IP - 5 4099 - http://erj.ersjournals.com/content/39/5/1097.short 4100 - http://erj.ersjournals.com/content/39/5/1097.full SO - Eur Respir J2012 May 01; 39 AB - Cardiovascular disease is common in chronic obstructive pulmonary disease (COPD) and raised troponin is common in exacerbations. However, the prevalence of myocardial infarction following hospitalisation for exacerbation of COPD is unknown. Patients aged ≥40 yrs hospitalised with acute exacerbation of COPD (n=242) with ≥10 pack-yrs of cigarette smoking were included in a prospective case series conducted in four hospitals. Patients whose primary presenting complaint was chest pain or who had an alternative diagnosis were excluded. Chest pain histories, serial ECGs and troponin levels were obtained. The mean±sd age was 69±9 yrs; 108 (45%) patients were male and almost half were current smokers. 124 (51%; 95% CI 48–58%) patients had chest pain, which was exertional in 62 (26%). 24 (10%) had raised troponin, among whom, 20 (8.3%; 95% CI 5.1–12.5%) had chest pain and/or serial ECG changes, fulfilling the 2007 Universal Definition of Myocardial Infarction. Neither chest pain (p=0.77) nor serial ECG changes (p=0.39) were associated with raised troponin. Raised troponin, chest pain and serial ECG changes are common in patients admitted to hospital with exacerbation of COPD. Overall, one in 12 patients met the criteria for myocardial infarction. Whether these patients would benefit from further cardiac investigation is unknown.