RT Journal Article SR Electronic T1 Long-term follow-up after bronchoscopic lung volume reduction in patients with emphysema JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1084 OP 1089 DO 10.1183/09031936.00071311 VO 39 IS 5 A1 Federico Venuta A1 Marco Anile A1 Daniele Diso A1 Carolina Carillo A1 Tiziano De Giacomo A1 Antonio D'Andrilli A1 Francesco Fraioli A1 Erino A. Rendina A1 Giorgio F. Coloni YR 2012 UL http://erj.ersjournals.com/content/39/5/1084.abstract AB Bronchoscopic lung volume reduction (BLVR) is a novel emphysema therapy. We evaluated long-term outcome in patients with heterogeneous emphysema undergoing BLVR with one-way valves. 40 patients undergoing unilateral BLVR entered our study. Pre-operative mean forced expiratory volume in 1 s (FEV1) was 0.88 L·s−1 (23%), total lung capacity was 7.45 L (121%), intrathoracic gas volume was 6 L (174%), residual volume (RV) was 5.2 L (232%), and the 6-min walk test (6MWT) was 286 m. All patients required supplemental oxygen; the Medical Research Council (MRC) dyspnoea score was 3.9. High-resolution computed tomography (HRCT) results were reviewed to assess the presence of interlobar fissures. 33 patients had a follow-up of >12 months (median 32 months). 37.5% of the patients had visible interlobar fissures. 40% of the patients died during follow-up. Three patients were transplanted and one underwent lung volume reduction surgery. Supplemental oxygen, FEV1, RV, 6MWT and MRC score showed a statistically significant improvement (p≤0.0001, p=0.004, p=0.03, p=0.003 and p<0.0001, respectively). Patients with visible fissures had a functional advantage. BLVR is feasible and safe. Long-term sustained improvements can be achieved. HRCT-visible interlobar fissures are a favourable prognostic factor.