TY - JOUR T1 - Factors associated with hospital mortality in community-acquired legionellosis in France JF - European Respiratory Journal JO - Eur Respir J SP - 963 LP - 970 DO - 10.1183/09031936.00076911 VL - 39 IS - 4 AU - C. Chidiac AU - D. Che AU - S. Pires-Cronenberger AU - S. Jarraud AU - C. Campèse AU - A. Bissery AU - P. Weinbreck AU - C. Brun-Buisson AU - J-P. Sollet AU - R. Ecochard AU - J-C. Desenclos AU - J. Etienne AU - P. Vanhems AU - the French Legionnaires’ Disease Study Group Y1 - 2012/04/01 UR - http://erj.ersjournals.com/content/39/4/963.abstract N2 - The aims of this study were to describe the clinical, biological and radiological features of community-acquired (CA) Legionnaires’ disease (LD) and identify the predictors of mortality in hospitalised patients. Demographic data, risk factors, clinical and biological features, medical management, complications, and outcome from 540 hospitalised patients with confirmed CA LD were prospectively recorded. 8.1% of patients (44 out of 540) died. The predictors of survival after Kaplan–Meier analysis were male sex (p=0.01), age <60 yrs (p=0.02), general symptoms (p=0.006), intensive care unit (ICU) stay (p<0.001), and class II–III Pneumonia Severity Index score (p=0.004). Six predictors of death were identified by multivariate analysis: age (per 10-yr increment) (relative hazard (RH) 1.50, 95% CI 1.21–1.87), female sex (RH 2.00, 95% CI 1.08–3.69), ICU admission (RH 3.31, 95% CI 1.67–6.56), renal failure (RH 2.73, 95% CI 1.42–5.27), corticosteroid therapy (RH 2.54, 95% CI 1.04–6.20) and C-reactive protein (CRP) >500 mg·L−1 (RH 2.14, 95% CI 1.02–4.48). Appropriate antibiotic therapy was prescribed for 70.8% (292 out of 412) of patients after admission and for 99.8% (537 out of 538) of patients after diagnosis confirmation. In conclusion, female sex, age, ICU stay, renal failure, corticosteroid treatment and increased level of CRP are significant risk factors for mortality in CA LD. ER -