PT  - JOURNAL ARTICLE
AU  - Lindberg, C.A.
AU  - Engström, G.
AU  - de Verdier, M. Gerhardsson
AU  - Nihlén, U.
AU  - Anderson, M.
AU  - Forsman-Semb, K.
AU  - Svartengren, M.
TI  - Total desmosines in plasma and urine correlate with lung function
AID  - 10.1183/09031936.00064611
DP  - 2012 Apr 01
TA  - European Respiratory Journal
PG  - 839--845
VI  - 39
IP  - 4
4099  - http://erj.ersjournals.com/content/39/4/839.short
4100  - http://erj.ersjournals.com/content/39/4/839.full
SO  - Eur Respir J2012 Apr 01; 39
AB  - The aim of the present study was to evaluate the relationship between the matrix degradation biomarkers, desmosine and isodesmosine (desmosines), and lung function. Plasma and creatinine-corrected urinary total desmosines (P- and U-desmosines, respectively), lung function and diffusing capacity of the lung for carbon monoxide (DL,CO) were measured in a cohort of subjects from the Swedish Twin Registry. Concentrations of U- and P-desmosines were measured in 349 and 318 subjects, respectively; approximately one-third of subjects had chronic obstructive pulmonary disease (COPD). Age, female sex, body mass index (BMI) and smoking were significantly associated with U-desmosines in a multiple linear regression analysis. In the overall population, after adjustments for age, sex, height, BMI and smoking, concentrations of U-desmosines were significantly correlated with all lung function measures, and P-desmosines with forced expiratory volume in 1 s and DL,CO (p<0.05). With the exception of residual volume versus P-desmosines, relationships between concentrations of desmosines and lung function measures were markedly stronger in subjects with COPD compared with those without COPD. These cross-sectional data showing associations between desmosines and several lung function variables suggest that desmosines, particularly U-desmosines, could be a useful biomarker of COPD status.