RT Journal Article
SR Electronic
T1 Extracellular matrix composition in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1362
OP 1373
DO 10.1183/09031936.00192611
VO 40
IS 6
A1 Raquel Annoni
A1 Tatiana Lanças
A1 Ryan Yukimatsu Tanigawa
A1 Marcus de Medeiros Matsushita
A1 Sandra de Morais Fernezlian
A1 Andreina Bruno
A1 Luiz Fernando Ferraz da Silva
A1 Peter J. Roughley
A1 Salvatore Battaglia
A1 Marisa Dolhnikoff
A1 Pieter S. Hiemstra
A1 Peter J. Sterk
A1 Klaus F. Rabe
A1 Thais Mauad
YR 2012
UL http://erj.ersjournals.com/content/40/6/1362.abstract
AB Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction. We determined the fractional areas of elastic fibres, type-I, -III and -IV collagen, versican, decorin, biglycan, lumican, fibronectin and tenascin in different compartments of the large and small airways and lung parenchyma in 26 COPD patients, 26 smokers without COPD and 16 nonsmoking control subjects. The fractional area of elastic fibres was higher in non-obstructed smokers than in COPD and nonsmoking controls, in all lung compartments. Type-I collagen fractional area was lower in the large and small airways of COPD patients and in the small airways of non-obstructed smokers than in nonsmokers. Compared with nonsmokers, COPD patients had lower versican fractional area in the parenchyma, higher fibronectin fractional area in small airways and higher tenascin fractional area in large and small airways compartments. In COPD patients, significant correlations were found between elastic fibres and fibronectin and lung function parameters. Alterations of the major ECM components are widespread in all lung compartments of patients with COPD and may contribute to persistent airflow obstruction.