RT Journal Article
SR Electronic
T1 Endothelin-1 and interleukin-8 in high altitude pulmonary oedema
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1947
OP 1949
DO 10.1183/09031936.96.09091947
VO 9
IS 9
A1 Y Droma
A1 T Hayano
A1 Y Takabayashi
A1 T Koizumi
A1 K Kubo
A1 T Kobayashi
A1 M Sekiguchi
YR 1996
UL http://erj.ersjournals.com/content/9/9/1947.abstract
AB We present a case of high altitude pulmonary oedema (HAPE) with pulmonary hypertension and polymorphonuclear leucocyte (PMN) accumulation in bronchoalveolar lavage fluid (BALF), which occurred in a 21 year old man. Plasma endothelin-1 (ET-1) and interleukin-8 (IL-8) concentration in BALF were elevated on admission, and returned to normal level at recovery, when the pulmonary artery pressure and the PMN counts in BALF were normal. In addition, E-selectin and intercellular adhesion molecule-1 (ICAM-1) in BALF were also slightly increased on admission. These findings suggest that endothelin-1 is a vasoconstrictor which contributes to the pulmonary hypertension in high altitude pulmonary oedema, and that some of the inflammatory mediators play an important role in chemotaxis and accumulation of polymorphonuclear leucocytes in the development of high altitude pulmonary oedema.