TY - JOUR T1 - Dietary factors and lung function in the general population: wine and resveratrol intake JF - European Respiratory Journal JO - Eur Respir J SP - 385 LP - 391 DO - 10.1183/09031936.00184110 VL - 39 IS - 2 AU - M. Siedlinski AU - J.M.A. Boer AU - H.A. Smit AU - D.S. Postma AU - H.M. Boezen Y1 - 2012/02/01 UR - http://erj.ersjournals.com/content/39/2/385.abstract N2 - Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT)1 activity. We assessed the impact of wine and resveratrol intake, and SIRT1 single-nucleotide polymorphisms (SNPs) on lung function in the general population. Effects of red and white wine and resveratrol intake on forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC were analysed in the population-based Doetinchem cohort (n=3,224). Associations of four tagging SIRT1 SNPs with lung function were analysed in the Doetinchem (n=1,152) and Vlagtwedde–Vlaardingen (n=1,390) cohorts. Resveratrol intake was associated with higher FVC levels, and white wine intake with higher FEV1 levels and lower risk of airway obstruction. SIRT1 SNPs were not significantly associated with level or course of lung function, either directly or indirectly via wine or resveratrol intake. This study shows a positive association of resveratrol intake with lung function in the general population, confirms the previously reported positive association of white wine intake with higher levels of FEV1, and additionally shows an association with a higher FEV1/FVC ratio. These effects probably do not run via SNPs in SIRT1. ER -