TY - JOUR T1 - Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis JF - European Respiratory Journal JO - Eur Respir J SP - 359 LP - 365 DO - 10.1183/09031936.00108111 VL - 39 IS - 2 AU - J.L. Hook AU - S.M. Arcasoy AU - D. Zemmel AU - M.N. Bartels AU - S.M. Kawut AU - D.J. Lederer Y1 - 2012/02/01 UR - http://erj.ersjournals.com/content/39/2/359.abstract N2 - The supplemental oxygen flow rate is a common bedside measure of gas exchange impairment. We aimed to determine whether a titrated oxygen requirement (TOR) predicted mortality in idiopathic pulmonary fibrosis (IPF). We examined 104 adults with IPF enrolled in a prospective cohort study and a validation cohort of 151 adults with a variety of interstitial lung diseases (ILDs). The TOR was defined as the lowest oxygen flow rate required to maintain an oxyhaemoglobin saturation of 96% while standing. Cox proportional hazards models and time-dependent receiver operating characteristic curves were used to examine survival time. A higher TOR was associated with a greater mortality rate independent of forced vital capacity and 6-min walk test results in IPF (adjusted hazard ratio (per 1 L·min−1) 1.16, 95% CI 1.06–1.27). The TOR was at least as accurate as pulmonary function and 6-min walk testing at predicting 1-yr mortality. Findings were similar in other ILDs. The TOR is a simple, inexpensive bedside measurement that aids prognostication in IPF. ER -