RT Journal Article
SR Electronic
T1 The association between resting and mild-to-moderate exercise pulmonary artery pressure
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 313
OP 318
DO 10.1183/09031936.00019911
VO 39
IS 2
A1 K. Whyte
A1 S. Hoette
A1 P. Herve
A1 D. Montani
A1 X. Jaïs
A1 F. Parent
A1 L. Savale
A1 D. Natali
A1 D.S. O'Callaghan
A1 G. Garcia
A1 O. Sitbon
A1 G. Simonneau
A1 M. Humbert
A1 D. Chemla
YR 2012
UL http://erj.ersjournals.com/content/39/2/313.abstract
AB The mean pulmonary artery pressure (P̄pa) achieved on mild-to-moderate exercise is age related and its haemodynamic correlates remain to be documented in patients free of pulmonary hypertension (PH). Our retrospective study involved patients free of PH investigated in our centre for possible pulmonary vascular disease between January 1, 2007 and October 31, 2009 who underwent right heart catheterisation at rest and during supine exercise up to 60 W. The 38 out of 99 patients aged <50 yrs were included and a P̄pa of 30 mmHg was considered the upper limit of normal on exercise. The 24 subjects who developed P̄pa>30 mmHg on exercise had higher resting P̄pa (19±3 versus 15±4 mmHg) and indexed pulmonary vascular resistance (PVRi; 3.4±1.5 versus 2.2±1.1 WU·m2; p<0.05) than the remaining 14 subjects. Resting P̄pa >15 mmHg predicted exercise P̄pa >30 mmHg with 88% sensitivity and 57% specificity. The eight patients with resting P̄pa 22–24 mmHg all had exercise P̄pa >30 mmHg. In subjects aged <50 yrs investigated for possible pulmonary vascular disease and free of PH, patients with mild-to-moderate exercise P̄pa >30 mmHg had higher resting PVRi and higher resting P̄pa, although there was no resting P̄pa threshold value that could predict normal response on mild-to-moderate exercise. The clinical relevance of such findings deserves further long-term follow-up studies.