RT Journal Article
SR Electronic
T1 Multi-symptom asthma as an indication of disease severity in epidemiology
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 825
OP 832
DO 10.1183/09031936.00143710
VO 38
IS 4
A1 L. Ekerljung
A1 A. Bossios
A1 J. Lötvall
A1 A-C. Olin
A1 E. Rönmark
A1 G. Wennergren
A1 K. Torén
A1 B. Lundbäck
YR 2011
UL http://erj.ersjournals.com/content/38/4/825.abstract
AB Epidemiological questionnaires have failed to identify individuals with severe asthma. The extent of symptoms of asthma can, however, be easily established in epidemiology, by identification of multiple symptoms. We hypothesise that reporting of multiple symptoms of asthma reflects uncontrolled disease and is a sign of more severe asthma. The aims of the current study were, therefore, to determine the prevalence and determinants of multi-symptom asthma. A postal questionnaire was sent to 30,000 randomly selected individuals aged 16–75 yrs. A subgroup underwent clinical examinations. Multi-symptom asthma was defined as reported physician-diagnosed asthma, use of asthma medication, recurrent wheeze, attacks of shortness of breath and at least one additional respiratory symptom. The prevalence of multi-symptom asthma was 2.0%, and it was more common among females (2.4 versus 1.5%; p<0.001) and those with a body mass index >30 kg·m-2. Multi-symptom asthmatics had lower forced expiratory volume in 1 s, higher exhaled nitric oxide fraction and more pronounced hyperresponsiveness. Family history of both asthma and allergy (OR 7.3), and occupational exposure to gas dust or fumes (OR 2.0) were also significant risk factors. Multi-symptom asthmatics comprise 2% of the general population; multi-symptom asthma is related to signs of more severe disease and could be used as an epidemiological marker of disease severity.