TY - JOUR T1 - Occupational asthma due to ceftazidime JF - European Respiratory Journal JO - Eur Respir J SP - 1421 LP - 1423 DO - 10.1183/09031936.95.08081421 VL - 8 IS - 8 AU - SC Stenton AU - JH Dennis AU - DJ Hendrick Y1 - 1995/08/01 UR - http://erj.ersjournals.com/content/8/8/1421.abstract N2 - A worker employed in the manufacture of the new third generation cephalosporin antibiotic, ceftazidime, developed asthmatic symptoms, and a series of inhalation challenge tests was undertaken to investigate the problem. The inhalation of increasing daily doses of ceftazidime up to 3.2 mg, using a double-blind challenge protocol gave rise to symptoms, late asthmatic reactions, and increases in airway responsiveness to methacholine. A repeat challenge with the 3.2 mg dose additionally gave rise to a clear immediate reaction. Ceftazidime was, thus, shown to be capable of inducing occupational asthma. ER -