PT  - JOURNAL ARTICLE
AU  - Stenton, SC
AU  - Dennis, JH
AU  - Hendrick, DJ
TI  - Occupational asthma due to ceftazidime
AID  - 10.1183/09031936.95.08081421
DP  - 1995 Aug 01
TA  - European Respiratory Journal
PG  - 1421--1423
VI  - 8
IP  - 8
4099  - https://publications.ersnet.org//content/8/8/1421.short
4100  - https://publications.ersnet.org//content/8/8/1421.full
SO  - Eur Respir J1995 Aug 01; 8
AB  - A worker employed in the manufacture of the new third generation cephalosporin antibiotic, ceftazidime, developed asthmatic symptoms, and a series of inhalation challenge tests was undertaken to investigate the problem. The inhalation of increasing daily doses of ceftazidime up to 3.2 mg, using a double-blind challenge protocol gave rise to symptoms, late asthmatic reactions, and increases in airway responsiveness to methacholine. A repeat challenge with the 3.2 mg dose additionally gave rise to a clear immediate reaction. Ceftazidime was, thus, shown to be capable of inducing occupational asthma.