TY - JOUR T1 - Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood JF - European Respiratory Journal JO - Eur Respir J SP - 2419 LP - 2422 DO - 10.1183/09031936.96.09112419 VL - 9 IS - 11 AU - K Sato AU - H Takahashi AU - H Amano AU - T Uekusa AU - T Dambara AU - S Kira Y1 - 1996/11/01 UR - http://erj.ersjournals.com/content/9/11/2419.abstract N2 - We describe an 18 year old male with pulmonary interstitial and intra-alveolar cholesterol granulomas (PICG), which developed to severe respiratory failure over 15 yrs. The histological diagnosis was made on the basis of open lung biopsy findings at the age of 3 yrs and autopsy at 18 yrs of age. Although the pathological features of the lung were similar to that of paediatric patients with lipoid pneumonia coexisting with pulmonary alveolar proteinosis (PAP), gastro-oesophageal reflux (GOR) and a diverse group of severe primary diseases, the patient lacked evidence for any of these. We believe the present case provides a new example of a diffuse-type of lipoid pneumonia coexisting with pulmonary alveolar proteinosis, which we call cholesterol granulomas. ER -