PT  - JOURNAL ARTICLE
AU  - O Bjortuft
AU  - B Johansen
AU  - J Boe
AU  - A Foerster
AU  - E Holter
AU  - O Geiran
TI  - Daily home spirometry facilitates early detection of rejection in single lung transplant recipients with emphysema
AID  - 10.1183/09031936.93.06050705
DP  - 1993 May 01
TA  - European Respiratory Journal
PG  - 705--708
VI  - 6
IP  - 5
4099  - http://erj.ersjournals.com/content/6/5/705.short
4100  - http://erj.ersjournals.com/content/6/5/705.full
SO  - Eur Respir J1993 May 01; 6
AB  - Eight single lung transplant recipients with emphysema, aged 40-58 yrs, have been followed up for 90 patient months. Starting 2-4 weeks postoperatively, they recorded their forced vital capacity (FVC), and forced expiratory volume in one second (FEV1), at a fixed time every morning using a Micro Spirometer. They were instructed to contact the hospital if the FVC or FEV1 displayed a persistent (two days or more) decrease of 10%, compared with the average values during the last seven days. Transbronchial biopsies (TBB) were performed regularly in the follow-up, and whenever the patients had respiratory symptoms, or the FVC or FEV1 displayed a persistent decline of more than 10%. We performed 59 TBBs, and 23 biopsy specimens showed rejection. The FVC and FEV1 values on the TBB day were compared with the mean values of the 7 previous days. FVC and FEV1, associated with negative TBBs (16 events), showed no significant changes. However, FVC and FEV1 decreased significantly (p < 0.001, paired t-test) during rejections (mean percentage change 14 and 21% respectively, range +8% to -53%). In 16 of the 23 rejections, the FEV1 decreased by > 10%. We recommend the use of daily home spirometry when monitoring single lung recipients with emphysema, and suggest that a persistent 10% decrease in FEV1 or FVC for at least two days is an indication for hospital admission and possible TBB.