PT  - JOURNAL ARTICLE
AU  - Comis, A
AU  - Valletta, EA
AU  - Sette, L
AU  - Andreoli, A
AU  - Boner, AL
TI  - Comparison of nedocromil sodium and sodium cromoglycate administered by pressurized aerosol, with and without a spacer device in exercise-induced asthma in children
DP  - 1993 Apr 01
TA  - European Respiratory Journal
PG  - 523--526
VI  - 6
IP  - 4
4099  - http://erj.ersjournals.com/content/6/4/523.short
4100  - http://erj.ersjournals.com/content/6/4/523.full
SO  - Eur Respir J1993 Apr 01; 6
AB  - To compare the effectiveness of nedocromil sodium (NS) and sodium cromoglycate (SCG) administered by metered dose inhaler (MDI) in preventing exercise-induced asthma (EIA), 12 asthmatic children with EIA were studied in a randomized, double-blind, cross-over, placebo-controlled study. NS and SCG were given by MDI alone, and by MDI with a 700 ml spacer device (Fisonair, Fisons, UK), in order to assess the benefit of using such a device. Following a baseline exercise challenge, the protective effect of NS, SCG or placebo was evaluated in each subject. The percentage fall in forced expiratory volume in one second, and percentage protection were measured. NS and SCG provided a significant and comparable protection from EIA, and both were better than placebo. No further improvement was observed after drug administration via the spacer. Both NS and SCG are effective in preventing EIA in children, when administered at the recommended clinical dose, and the use of a spacer for administering the drug provides no advantage if the technique of inhalation is good.