PT  - JOURNAL ARTICLE
AU  - Molimard, M
AU  - Advenier, C
TI  - Effect of frusemide on bradykinin- and capsaicin-induced contraction of the guinea-pig trachea
AID  - 10.1183/09031936.93.06030434
DP  - 1993 Mar 01
TA  - European Respiratory Journal
PG  - 434--439
VI  - 6
IP  - 3
4099  - http://erj.ersjournals.com/content/6/3/434.short
4100  - http://erj.ersjournals.com/content/6/3/434.full
SO  - Eur Respir J1993 Mar 01; 6
AB  - Frusemide, a loop diuretic, inhibits the bronchial response to various bronchoconstrictor stimuli in asthmatic subjects. The underlying mechanisms remain unclear. In order to determine whether frusemide inhibits pharmacologically induced C-fibre stimulation, we investigated the effect of frusemide on bradykinin-, capsaicin-, neurokinin A-, and substance P-induced contraction of the guinea-pig isolated trachea. Frusemide 10(-5) and 10(-4) M produced a significant inhibition of concentration-response curves to bradykinin, which was markedly reduced by indomethacin 10(-6) M. Frusemide significantly reduced capsaicin-induced contraction only in the presence of indomethacin 10(-6) M. Neurokinin A- and substance P-induced contractions were not affected by frusemide and/or indomethacin. Our data suggest that a cyclo-oxygenase pathway is involved in the inhibition by frusemide of the bradykinin-induced contraction, but not in the inhibition of the capsaicin-induced contraction.