RT Journal Article
SR Electronic
T1 Endobronchial presentation of Hodgkin's disease: a report of nine cases and review of the literature
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1852
OP 1855
DO 10.1183/09031936.94.07101852
VO 7
IS 10
A1 J Tredaniel
A1 I Peillon
A1 C Ferme
A1 P Brice
A1 C Gisselbrecht
A1 A Hirsch
YR 1994
UL http://erj.ersjournals.com/content/7/10/1852.abstract
AB Although mediastinal involvement by Hodgkin's disease is frequent, the initial presentation of the lymphoma by an endobronchial lesion is rare. Therefore, the question of whether patients with Hodgkin's disease should undergo fibreoptic bronchoscopy as a staging procedure remains unresolved. In a series of 469 patients with newly diagnosed Hodgkin's disease during a 10 year period, we reviewed the clinical features of nine patients who presented with an endobronchial tumour. They were compared to 34 previously published cases. The major presenting symptoms were cough, wheezing and haemoptysis. Bulky mediastinum was seen in six cases. The three other patients presented respiratory symptoms evocative of endoluminal invasion. All but one of the patients received combined modality therapy, as currently accepted for patients with poor prognostic factors. The overall actuarial survival was 74% after 4 yrs of follow-up. A selective subgroup of patients with stage I-II supradiaphragmatic and endobronchial Hodgkin's disease may, thus, present without poor prognostic factors (but generally with respiratory symptoms), and might be undertreated if this localization is not recognized. We propose that these patients should undergo fibreoptic bronchoscopy.