@article {Thorsson1839, author = {L Thorsson and S Edsbacker and TB Conradson}, title = {Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI}, volume = {7}, number = {10}, pages = {1839--1844}, year = {1994}, doi = {10.1183/09031936.94.07101839}, publisher = {European Respiratory Society}, abstract = {The pulmonary and systemic availability of budesonide after inhalation from a dry powder inhaler, Turbuhaler, and from a pressurized metered-dose inhaler (P-MDI) were compared in healthy volunteers. Two different methods were used to assess pulmonary availability: 1) calculated from the systemic availability corrected for an oral availability of 13\% (n = 24); and 2) after blocking of gastrointestinal absorption by administration of a charcoal suspension (n = 13). An intravenous infusion of budesonide was used as a reference. The systemic availability of budesonide, calculated as a geometric mean and expressed as percentage of the metered dose, was 38\% for Turbuhaler and 26\% for P-MDI. The pulmonary availability, calculated using the first method, was 32\% and 15\% for Turbuhaler and P-MDI, respectively; and, using the second method, 32\% and 18\%, respectively. The results of the present study indicate that administration of budesonide via Turbuhaler gives rise to a lung deposition which is approximately twice that of a P-MDI, with less variability, but that systemic availability is only increased by approximately 50\%. Thus, the present data suggest that by administrating budesonide via Turbuhaler, instead of a P-MDI, the same degree of asthma control can be achieved with a lower dose, which, in turn, reduces the risk of undesired systemic effects.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/7/10/1839}, eprint = {https://erj.ersjournals.com/content/7/10/1839.full.pdf}, journal = {European Respiratory Journal} }