TY - JOUR T1 - Relationship of upper airways disorders to FEV1 and bronchial hyperresponsiveness in an epidemiological study JF - European Respiratory Journal JO - Eur Respir J SP - 1104 LP - 1110 DO - 10.1183/09031936.93.05091104 VL - 5 IS - 9 AU - I Annesi AU - MP Oryszczyn AU - F Neukirch AU - E Orvoen-Frija AU - M Korobaeff AU - F Kauffmann Y1 - 1992/10/01 UR - http://erj.ersjournals.com/content/5/9/1104.abstract N2 - Associations of upper airways disorders (UAD) with forced expiratory volume in one second (FEV1) and bronchial methacholine response were studied, taking smoking habits into account. We used epidemiological data drawn from a population of 324 men, aged 27-58 yrs. Lower FEV1 level was related to hay fever (p = 0.01), usual (p = 0.01) and chronic (p = 0.02) rhinitis and common cold on the day of examination (p = 0.04). Allowance for the major potential confounding factor, tobacco smoking, showed similar results. Bronchial methacholine response was heightened in men reporting hay fever compared to those without (p = 0.01) but also in men reporting chronic rhinitis (p = 0.06), a group which did not exhibit skin prick test positivity more often than other subjects. Exclusion of asthmatics and taking into account smoking and skin prick test positivity yielded mostly similar results. Our data support the hypothesis of an association between lung impairment, as assessed by lower FEV1 and bronchial hyperresponsiveness to methacholine, and different types of UAD, allergic or not. ER -