@article {Luj{\'a}n1073, author = {M. Luj{\'a}n and M. Gallego and Y. Belmonte and D. Fontanals and J. Vall{\`e}s and T. Lisboa and J. Rello}, title = {Influence of pneumococcal serotype group on outcome in adults with bacteraemic pneumonia}, volume = {36}, number = {5}, pages = {1073--1079}, year = {2010}, doi = {10.1183/09031936.00176309}, publisher = {European Respiratory Society}, abstract = {The influence of infecting serotype group on outcome in bacteraemic pneumococcal pneumonia remains unclear. We performed a prospective, 10-yr observational study in an 800-bed teaching hospital. 299 adults diagnosed with pneumonia whose blood cultures showed growth of Streptococcus pneumoniae were included in the study. High invasive disease potential (H) serotypes included serotypes 1, 5 and 7F, which served as a reference category, were compared with low invasive disease potential (L) serotypes (3, 6A, 6B, 8, 19F, and 23F) and other (O) serotypes (non-H, non-L). The influence on outcome was determined for each group of serotypes after adjusting for underlying conditions and severity of illness at admission. Overall, 30-day mortality was 11\%. H serotypes (n = 93) infected primarily younger people and presented a higher risk of complicated parapneumonic effusion or empyema (17.2 versus 5.1\%; p = 0.01), with lower mortality (3.2\%). The isolation of L serotypes (n = 78) was an independent risk factor for 30-day mortality (OR 7.02, 95\% CI 1.72{\textendash}28.61), as were Charlson score (OR 1.30, 95\% CI 1.08{\textendash}1.58), alcohol abuse (OR 3.99, 95\% CI 1.39{\textendash}11.39) and severity of illness measured by American Thoracic Society (ATS)/Infectious Diseases Society of America (IDSA) criteria (OR 4.80, 95\% CI 1.89{\textendash}12.13). A vaccination strategy including serotypes 3, 6A, 6B, 8, 19F and 23F may improve survival in adults.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/36/5/1073}, eprint = {https://erj.ersjournals.com/content/36/5/1073.full.pdf}, journal = {European Respiratory Journal} }