RT Journal Article
SR Electronic
T1 Exhaled nitric oxide, susceptibility and new-onset asthma in the Children’s Health Study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 523
OP 531
DO 10.1183/09031936.00021210
VO 37
IS 3
A1 T.M. Bastain
A1 T. Islam
A1 K.T. Berhane
A1 R.S. McConnell
A1 E.B. Rappaport
A1 M.T. Salam
A1 W.S. Linn
A1 E.L. Avol
A1 Y. Zhang
A1 F.D. Gilliland
YR 2011
UL http://erj.ersjournals.com/content/37/3/523.abstract
AB A substantial body of evidence suggests an aetiological role of inflammation, and oxidative and nitrosative stress in asthma pathogenesis. Exhaled nitric oxide fraction (FeNO) may provide a noninvasive marker of oxidative and nitrosative stress, and aspects of airway inflammation. We examined whether children with elevated FeNO are at increased risk for new-onset asthma. We prospectively followed 2,206 asthma-free children (age 7–10 yrs) who participated in the Children’s Health Study. We measured FeNO and followed these children for 3 yrs to ascertain incident asthma cases. Cox proportional hazard models were fitted to examine the association between FeNO and new-onset asthma. We found that FeNO was associated with increased risk of new-onset asthma. Children in the highest FeNO quartile had more than a two-fold increased risk of new-onset asthma compared to those with the lowest quartile (hazard ratio 2.1, 95% CI 1.3–3.5). This effect did not vary with the child’s history of respiratory allergic symptoms. However, the effect of elevated FeNO on new-onset asthma was most apparent among those without a parental history of asthma. Our results indicate that children with elevated FeNO are at increased risk for new-onset asthma, especially if they have no parental history of asthma.