@article {Bastain523, author = {T.M. Bastain and T. Islam and K.T. Berhane and R.S. McConnell and E.B. Rappaport and M.T. Salam and W.S. Linn and E.L. Avol and Y. Zhang and F.D. Gilliland}, title = {Exhaled nitric oxide, susceptibility and new-onset asthma in the Children{\textquoteright}s Health Study}, volume = {37}, number = {3}, pages = {523--531}, year = {2011}, doi = {10.1183/09031936.00021210}, publisher = {European Respiratory Society}, abstract = {A substantial body of evidence suggests an aetiological role of inflammation, and oxidative and nitrosative stress in asthma pathogenesis. Exhaled nitric oxide fraction (FeNO) may provide a noninvasive marker of oxidative and nitrosative stress, and aspects of airway inflammation. We examined whether children with elevated FeNO are at increased risk for new-onset asthma. We prospectively followed 2,206 asthma-free children (age 7{\textendash}10 yrs) who participated in the Children{\textquoteright}s Health Study. We measured FeNO and followed these children for 3 yrs to ascertain incident asthma cases. Cox proportional hazard models were fitted to examine the association between FeNO and new-onset asthma. We found that FeNO was associated with increased risk of new-onset asthma. Children in the highest FeNO quartile had more than a two-fold increased risk of new-onset asthma compared to those with the lowest quartile (hazard ratio 2.1, 95\% CI 1.3{\textendash}3.5). This effect did not vary with the child{\textquoteright}s history of respiratory allergic symptoms. However, the effect of elevated FeNO on new-onset asthma was most apparent among those without a parental history of asthma. Our results indicate that children with elevated FeNO are at increased risk for new-onset asthma, especially if they have no parental history of asthma.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/37/3/523}, eprint = {https://erj.ersjournals.com/content/37/3/523.full.pdf}, journal = {European Respiratory Journal} }