TY - JOUR T1 - Efficacy of standard rehabilitation in COPD outpatients with comorbidities JF - European Respiratory Journal JO - Eur Respir J SP - 1042 LP - 1048 DO - 10.1183/09031936.00203809 VL - 36 IS - 5 AU - E. Crisafulli AU - P. Gorgone AU - B. Vagaggini AU - M. Pagani AU - G. Rossi AU - F. Costa AU - V. Guarriello AU - P. Paggiaro AU - A. Chetta AU - F. de Blasio AU - D. Olivieri AU - L.M. Fabbri AU - E.M. Clini Y1 - 2010/11/01 UR - http://erj.ersjournals.com/content/36/5/1042.abstract N2 - A prospective study was performed to confirm the prevalence pattern of the most frequent co-morbidities and to evaluate whether characteristics of patients, specific comorbidities and increasing number of comorbidities are independently associated with poorer outcomes in a population with complex chronic obstructive pulmonary disease (COPD) submitted for pulmonary rehabilitation (PR). 316 outpatients (mean±sd age 68±7 yrs) were studied. The outcomes recorded were comorbidities and proportion of patients with a pre-defined minimally significant change in exercise tolerance (6-min walk distance (6MWD) +54 m), breathlessness (Medical Research Council (MRC) score -1 point) and quality of life (St George’s Respiratory Questionnaire -4 points). 62% of patients reported comorbidities; systemic hypertension (35%), dyslipidaemia (13%), diabetes (12%) and coronary disease (11%) were the most frequent. Of these patients, >45% improved over the minimum clinically important difference in all the outcomes. In a logistic regression model, baseline 6MWD (OR 0.99, 95% CI 0.98–0.99; p = 0.001), MRC score (OR 12.88, 95% CI 6.89–24.00; p = 0.001) and arterial carbon dioxide tension (OR 1.08, 95% CI 1.00–1.15; p = 0.034) correlated with the proportion of patients who improved 6MWD and MRC, respectively. Presence of osteoporosis reduced the success rate in 6MWD (OR 0.28, 95% CI 0.11–0.70; p = 0.006). A substantial prevalence of comorbidities in COPD outpatients referred for PR was confirmed. Only the individual's disability and the presence of osteoporosis were independently associated with poorer rehabilitation outcomes. ER -