PT  - JOURNAL ARTICLE
AU  - Y Bogaerts
AU  - D Van Renterghem
AU  - J Vanvuchelen
AU  - M Praet
AU  - P Michielssen
AU  - V Blaton
AU  - JP Willemot
TI  - Interstitial pneumonitis and pulmonary vasculitis in a patient taking an L-tryptophan preparation
AID  - 10.1183/09031936.93.04081033
DP  - 1991 Sep 01
TA  - European Respiratory Journal
PG  - 1033--1036
VI  - 4
IP  - 8
4099  - http://erj.ersjournals.com/content/4/8/1033.short
4100  - http://erj.ersjournals.com/content/4/8/1033.full
SO  - Eur Respir J1991 Sep 01; 4
AB  - A case is presented of interstitial pneumonitis and pulmonary vasculitis ascribed to the ingestion of an L-tryptophan preparation. An unintended rechallenge supported the causal relationship. There was neither myalgia nor peripheral eosinophilia. Bronchoalveolar lavage fluid contained 12% eosinophils but few were present in the surgical lung biopsy specimen. Lung infiltrates receded after withdrawal of the drug and treatment with steroids. Dyspnoea and pulmonary hypertension persisted. Cyclophosphamide had no effect. Sclerodermiform skin lesions appeared as a late sequel. Chromatographic analysis of the L-tryptophan revealed no suspect impurities.