RT Journal Article
SR Electronic
T1 The distribution of temafloxacin in bronchial epithelial lining fluid, alveolar macrophages and bronchial mucosa
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 471
OP 476
DO 10.1183/09031936.93.05040471
VO 5
IS 4
A1 DR Baldwin
A1 R Wise
A1 JM Andrews
A1 JP Ashby
A1 D Honeybourne
YR 1992
UL http://erj.ersjournals.com/content/5/4/471.abstract
AB The concentrations of temafloxacin, a new fluoroquinolone antimicrobial, in the potential sites of pulmonary infection were assessed by fibreoptic bronchoscopy with bronchoalveolar lavage. Fourteen patients received a course of temafloxacin, 600 mg twice daily, for three days prior to sampling. The mean serum concentration was 9.6 (SEM 1.2) mg.l-1, compared with 14.9(SEM 1.8) mg.kg-1 for bronchial mucosa, 26.5 (SEM 3.6) mg.l-1 for epithelial lining fluid and 83.0 (SEM 11.5) mg.l-1 for alveolar macrophage. In the ten patients who completed the protocol, site concentrations correlated well with serum concentrations. Temafloxacin was concentrated in each of the potential sites of infection examined and is, therefore, a promising new agent for the treatment of respiratory tract infection.