PT  - JOURNAL ARTICLE
AU  - A Patessio
AU  - A Podda
AU  - M Carone
AU  - N Trombetta
AU  - CF Donner
TI  - Protective effect and duration of action of formoterol aerosol on exercise-induced asthma
AID  - 10.1183/09031936.93.04030296
DP  - 1991 Mar 01
TA  - European Respiratory Journal
PG  - 296--300
VI  - 4
IP  - 3
4099  - http://erj.ersjournals.com/content/4/3/296.short
4100  - http://erj.ersjournals.com/content/4/3/296.full
SO  - Eur Respir J1991 Mar 01; 4
AB  - The short-term protective effect on exercise-induced asthma (EIA) and the duration of action of formoterol, given by metered dose aerosol at a dose of 24 micrograms, were compared with salbutamol (200 micrograms) and placebo in twelve asthmatic EIA-positive patients in a double-blind, placebo-controlled, three period cross-over study. On each treatment day the patients were given one of the drugs or placebo and two exercise tests were performed at the second and at the eighth hour after dosing. Using a standard procedure, exercise was performed by treadmill in well-controlled environmental conditions. In the first test at 2 h a significant difference relative to placebo (p less than 0.001) at each incremental time after exercise (i.e. 5, 10, 15, 20, 30 min) was obtained with both formoterol and salbutamol, without any significant difference between formoterol and salbutamol. After the eighth hour test formoterol still protected against EIA in comparison to both salbutamol and placebo. The effect of salbutamol at this time was not different from placebo. No adverse effects were reported in any treatment group. Formoterol has a long duration of action in protecting against EIA that persisted for eight hours, removing the need to dose with beta 2-agonist before every exercise.