PT  - JOURNAL ARTICLE
AU  - Strom, K
AU  - Odeberg, H
AU  - Andersson, AC
AU  - Boe, J
AU  - Singer, J
AU  - Svensson, G
TI  - S-erythropoietin levels decrease in patients with chronic hypoxia starting domiciliary oxygen therapy
AID  - 10.1183/09031936.93.04070820
DP  - 1991 Jul 01
TA  - European Respiratory Journal
PG  - 820--823
VI  - 4
IP  - 7
4099  - https://publications.ersnet.org//content/4/7/820.short
4100  - https://publications.ersnet.org//content/4/7/820.full
SO  - Eur Respir J1991 Jul 01; 4
AB  - Consecutive determinations of erythropoietin in serum (s-Epo) were made in ten patients with chronic hypoxia starting domiciliary long-term oxygen therapy (LTO). After 24 h of supplementary oxygen treatment there was a fall in the median s-Epo level from 11.3 to 4.4 IU.l-1 (p less than 0.01). The initial decrease in s-Epo in conjunction with oxygen treatment was not sustained after one and three months of LTO. S-Epo levels above the reference range (3.3-13.5 IU.l-1) were found in three patients before and during LTO and in another two patients during LTO. Markedly elevated s-Epo levels were found in two patients with hypoxia and hypercapnia at the time of blood sampling. A significant negative relationship was found between the arterial oxygen tension and the log value for the s-Epo level (r = 0.40, p less than 0.005). The s-Epo levels were found to be normal in half of the measurements in patients using oxygen less than 15 h daily, a fact that indicates that s-Epo measurements are probably not suitable as indicators of compliance with LTO.