RT Journal Article SR Electronic T1 Screening for sleep-disordered breathing in neuromuscular disease using a questionnaire for symptoms associated with diaphragm paralysis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 400 OP 405 DO 10.1183/09031936.00036210 VO 37 IS 2 A1 J. Steier A1 C.J. Jolley A1 J. Seymour A1 H. Teschler A1 Y.M. Luo A1 M.I. Polkey A1 J. Moxham YR 2011 UL http://erj.ersjournals.com/content/37/2/400.abstract AB Patients with neuromuscular disease (NMD) are at risk of developing sleep-disordered breathing (SDB) following respiratory muscle involvement. We hypothesised that a questionnaire based on clinical symptoms and signs of diaphragm weakness can be used to screen for SDB in such patients. We developed a self-administered multiple choice questionnaire containing five questions (Sleep-Disordered Breathing in Neuromuscular Disease Questionnaire (SiNQ)-5), scoring 0–10 points. 125 patients were enrolled: 32 with respiratory muscle weakness, 35 subjects with normal respiratory muscle strength and 58 patients with obstructive sleep apnoea (OSA). All subjects underwent full polysomnography. NMD patients with involvement of the respiratory muscles scored mean±sd 6.8±2.3 out of 10 points, significantly higher than both OSA patients 2.5±2.3 and normal subjects 1.0±2.0 (p<0.001). A score of five or more points in the SiNQ-5 had a sensitivity of 86.2%, specificity of 88.5%, positive predictive value of 69.4% and a negative predictive value of 95.5% to identify NMD with combined SDB. A short self-administered questionnaire, the SiNQ-5, based on clinical symptoms can reliably screen for SDB in patients with diaphragm weakness. However, comorbidities, such as heart failure, that have symptoms influenced by posture could alter diagnostic accuracy.