TY - JOUR T1 - Factors associated with inflammatory cytokine patterns in community-acquired pneumonia JF - European Respiratory Journal JO - Eur Respir J SP - 393 LP - 399 DO - 10.1183/09031936.00040710 VL - 37 IS - 2 AU - R. Martínez AU - R. Menéndez AU - S. Reyes AU - E. Polverino AU - C. Cillóniz AU - A. Martínez AU - C. Esquinas AU - X. Filella AU - P. Ramírez AU - A. Torres Y1 - 2011/02/01 UR - http://erj.ersjournals.com/content/37/2/393.abstract N2 - Raised systemic levels of interleukin (IL)-6 and IL-10 cytokines have been associated with poorer outcome in community-acquired pneumonia. The aim of our study was to identify potential associated factors with increased levels of IL-6, IL-10, or both cytokines. We performed a prospective study of 685 patients admitted to hospital with community-acquired pneumonia. IL-6 and IL-10 were measured in blood in the first 24 h. 30-day mortality increased from 4.8% to 11.4% (p = 0.003) when both cytokines were higher than the median. Independent associated factors with an excess of IL-6 were neurologic disease, confusion, serum sodium <130 mEq·L−1, pleural effusion, and bacteraemia. The associated factors for an excess of IL-10 were respiratory rate ≥30 breaths·min−1, systolic blood pressure <90 mmHg and glycaemia ≥250 mg·dL−1. The independent associated factors for an excess of both cytokines were confusion, systolic blood pressure <90 mmHg, pleural effusion and bacteraemia. Protective factors were prior antibiotic treatment and pneumococcal vaccination. Different independent factors are related to an excess of IL-6 and IL-10. Confusion, hypotension, pleural effusion and bacteraemia were associated with the inflammatory profile with the highest mortality rate, whereas anti-pneumococcal vaccination and previous antibiotic treatment appeared to be protective factors. ER -