RT Journal Article
SR Electronic
T1 Isoniazid resistant tuberculosis in a school outbreak: the protective effect of BCG
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 778
OP 782
DO 10.1183/09031936.93.04070778
VO 4
IS 7
A1 A Shannon
A1 P Kelly
A1 M Lucey
A1 M Cooney
A1 P Corcoran
A1 L Clancy
YR 1991
UL http://erj.ersjournals.com/content/4/7/778.abstract
AB An outbreak of isoniazid resistant tuberculosis occurred in a large second level school. A total of 1,160 teenage pupils were at risk. Nineteen cases of tuberculosis were diagnosed, 15 were students, 9 of whom were among 251 non-vaccinated students and 6 among 909 vaccinated students. Two cases of miliary tuberculosis, one of whom also had tuberculous (TB) meningitis, occurred in the non-vaccinated group. The number of children with Heaf grade +3 or +4 was significantly greater among children who had been given Bacille Calmette-Guerin (BCG) vaccination (8 vs 4.4%). This suggests a boosting effect on the response in vaccinated children. The protective effect of neonatal BCG vaccination in this school outbreak suggests that it provides significant protection against tuberculosis lasting into adolescence.