PT  - JOURNAL ARTICLE
AU  - A Shannon
AU  - P Kelly
AU  - M Lucey
AU  - M Cooney
AU  - P Corcoran
AU  - L Clancy
TI  - Isoniazid resistant tuberculosis in a school outbreak: the protective effect of BCG
AID  - 10.1183/09031936.93.04070778
DP  - 1991 Jul 01
TA  - European Respiratory Journal
PG  - 778--782
VI  - 4
IP  - 7
4099  - http://erj.ersjournals.com/content/4/7/778.short
4100  - http://erj.ersjournals.com/content/4/7/778.full
SO  - Eur Respir J1991 Jul 01; 4
AB  - An outbreak of isoniazid resistant tuberculosis occurred in a large second level school. A total of 1,160 teenage pupils were at risk. Nineteen cases of tuberculosis were diagnosed, 15 were students, 9 of whom were among 251 non-vaccinated students and 6 among 909 vaccinated students. Two cases of miliary tuberculosis, one of whom also had tuberculous (TB) meningitis, occurred in the non-vaccinated group. The number of children with Heaf grade +3 or +4 was significantly greater among children who had been given Bacille Calmette-Guerin (BCG) vaccination (8 vs 4.4%). This suggests a boosting effect on the response in vaccinated children. The protective effect of neonatal BCG vaccination in this school outbreak suggests that it provides significant protection against tuberculosis lasting into adolescence.