RT Journal Article SR Electronic T1 The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 806 OP 812 DO 10.1183/09031936.00072510 VO 37 IS 4 A1 R. Amin A1 P. Subbarao A1 W. Lou A1 A. Jabar A1 S. Balkovec A1 R. Jensen A1 S. Kerrigan A1 P. Gustafsson A1 F. Ratjen YR 2011 UL http://erj.ersjournals.com/content/37/4/806.abstract AB Outcome measures to assess therapeutic interventions in cystic fibrosis (CF) patients with mild lung disease are lacking. Our aim was to determine if the lung clearance index (LCI) can detect a treatment response to dornase alfa in paediatric CF patients with normal spirometry.CF patients between 6–18 yrs of age with FEV1 ≥80% pred were eligible. In a crossover design, 17 patients received 4 weeks of dornase alfa and placebo in a randomised sequence separated by a 4-week washout period. The primary end-point was the change in LCI from dornase alfa versus placebo. A mixed model approach incorporating period-dependent baselines was used.The mean±sd age was 10.32±3.35 yrs. Dornase alfa improved LCI versus placebo (0.90±1.44; p = 0.022). Forced expiratory flow at 25–75% expired volume measured by % pred and z-scores also improved in subjects on dornase alfa (6.1%±10.34%; p = 0.03 and 0.28±0.46 z-score; p = 0.03).Dornase alfa significantly improved LCI. Therefore the LCI may be a suitable tool to assess early intervention strategies in this patient population.