RT Journal Article
SR Electronic
T1 Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1022
OP 1030
DO 10.1183/09031936.00079409
VO 35
IS 5
A1 W. Xu
A1 J-P. Collet
A1 S. Shapiro
A1 Y. Lin
A1 T. Yang
A1 C. Wang
A1 J. Bourbeau
YR 2010
UL http://erj.ersjournals.com/content/35/5/1022.abstract
AB Unreported chronic obstructive pulmonary disease (COPD) exacerbations are common, but their intermediate-to-long-term impacts on health-related quality of life (HRQoL) are unknown. The aim of the present study was to examine the impact of unreported exacerbations on HRQoL at 1 yr. A multicentric prospective cohort study in 491 COPD patients was conducted in China. HRQoL was measured using the St George's Respiratory Questionnaire (SGRQ). Other measurements included sociodemographic, clinical, psychosocial and treatment profiles. Patients were monitored monthly for 12 months to document exacerbations (at least one symptom worsening for ≥48 h). Patients were categorised into six groups: no exacerbation, one unreported exacerbation only, more than one unreported exacerbation only, one reported exacerbation only, more than one reported exacerbation only, and both unreported and reported exacerbations. Generalised estimating equations were used to estimate the adjusted associations between exacerbations and HRQoL change. A total of 466 unreported and 410 reported exacerbations were recorded. Compared with patients with no exacerbations, the change in SGRQ total score was similar amongst patients with one unreported exacerbation (adjusted mean change 1.22 points (95% CI -4.05–6.48)), but significantly worse among patients with more than one unreported exacerbation (4.61 (95% CI 0.09–9.13)). Development and evaluation of self-management programmes emphasising early recognition of exacerbations and consequent action appear to be warranted.