RT Journal Article
SR Electronic
T1 Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1346
OP 1353
DO 10.1183/09031936.00098509
VO 35
IS 6
A1 S. V. Kik
A1 W. P. J. Franken
A1 M. Mensen
A1 F. G. J. Cobelens
A1 M. Kamphorst
A1 S. M. Arend
A1 C. Erkens
A1 A. Gebhard
A1 M. W. Borgdorff
A1 S. Verver
YR 2010
UL http://erj.ersjournals.com/content/35/6/1346.abstract
AB The authors determined the positive predictive value (PPV) for progression to tuberculosis (TB) of two interferon-γ release assays (IGRAs), QuantiFERON-TB® Gold In-tube (QFT-GIT) and T-SPOT.TB®, and the tuberculin skin test (TST) in immigrants contacts. Immigrant close contacts of sputum smear-positive TB patients were included when aged ≥16 yrs and their TST result was ≥5 mm 0 or 3 months after diagnosis of the index patient. Contacts were followed for the next 2 yrs for development of TB disease. Of 339 immigrant contacts with TST ≥5 mm, 324 and 299 had valid results of QFT-GIT and T-SPOT.TB®, respectively. Nine contacts developed active TB. One patient had not been tested with TST, while another patient had not been tested with QFT-GIT and T-SPOT.TB®. The PPV for progression to TB during this period was 9/288 = 3.1% (95% CI 1.3–5.0%) for TST ≥10 mm, 7/184 = 3.8% (95% CI 1.7–5.9%) for TST ≥15 mm, 5/178 = 2.8% (95% CI 1.0–4.6%) for QFT-GIT and 6/181 = 3.3% (95% CI 1.3–5.3%) for T-SPOT.TB®. Sensitivity was 100%, 88%, 63% and 75%, respectively. The predictive values of QFT-GIT, T-SPOT.TB® and TST for progression to TB disease among immigrant close contacts were comparable.