RT Journal Article
SR Electronic
T1 Exhaled biomarkers in lung cancer
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 261
OP 275
DO 10.1183/09031936.00142508
VO 34
IS 1
A1 I. Horváth
A1 Z. Lázár
A1 N. Gyulai
A1 M. Kollai
A1 G. Losonczy
YR 2009
UL http://erj.ersjournals.com/content/34/1/261.abstract
AB Lung cancer is the leading cause of cancer death. Results of therapeutic interventions are particularly discouraging when the disease is discovered in an advanced stage. Early diagnosis is limited by the fact that the disease usually develops asymptomatically and available screening methods do not fulfil the requirements for reliable discrimination between patients with lung cancer and subjects not suffering from the disease. Breath sampling is completely noninvasive and provides a potentially useful approach to screening lung cancer. Exhaled biomarkers contain both volatile and nonvolatile molecules. The profile of volatile organic compounds is different in patients with lung cancer than in control subjects. In exhaled breath condensate, the proteomic profile of breath from cancer patients differs from that of healthy smokers. We reviewed the scientific evidence demonstrating that a unique chemical signature can be detected in the breath of patients with lung cancer and that the exhaled breath biomarker profile could aid clinical decision making. SERIES “LUNG CANCER” Edited by C. Brambilla Number 7 in this Series