RT Journal Article
SR Electronic
T1 Effects of exercise training in patients with idiopathic pulmonary arterial hypertension
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 669
OP 675
DO 10.1183/09031936.00027909
VO 34
IS 3
A1 F. S. de Man
A1 M. L. Handoko
A1 H. Groepenhoff
A1 A. J. van 't Hul
A1 J. Abbink
A1 R. J. H. Koppers
A1 H. P. Grotjohan
A1 J. W. R. Twisk
A1 H-J. Bogaard
A1 A. Boonstra
A1 P. E. Postmus
A1 N. Westerhof
A1 W. J. van der Laarse
A1 A. Vonk-Noordegraaf
YR 2009
UL http://erj.ersjournals.com/content/34/3/669.abstract
AB We determined the physiological effects of exercise training on exercise capacity and quadriceps muscle function in patients with idiopathic pulmonary arterial hypertension (iPAH). In total, 19 clinically stable iPAH patients (New York Heart Association II-III) underwent a supervised exercise training programme for the duration of 12 weeks. Maximal capacity, endurance capacity and quadriceps function were assessed at baseline and after 12 weeks. In 12 patients, serial quadriceps muscle biopsies were obtained. 6-min walk distance and peak exercise capacity did not change after training. However, endurance capacity improved significantly after training, demonstrated by a shift of the anaerobic threshold to a higher workload (from 32±5 to 46±6 W; p = 0.003) together with an increase in exercise endurance time (p<0.001). Moreover, exercise training increased quadriceps strength by 13% (p = 0.005) and quadriceps endurance by 34% (p = 0.001). Training enhanced aerobic capacity of the quadriceps, by increasing capillarisation (1.36±0.10 to 1.78±0.13 capillaries per muscle fibre; p<0.001) and oxidative enzyme activity, especially of the type-I (slow) muscle fibres. No changes were found in cross-sectional area and fibre type distribution. Exercise training in iPAH improves exercise endurance and quadriceps muscle function, which is also reflected by structural changes of the quadriceps.