RT Journal Article
SR Electronic
T1 Exhaled nitric oxide in cystic fibrosis: relationships with airway and lung vascular impairments
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 117
OP 124
DO 10.1183/09031936.00164508
VO 34
IS 1
A1 D. Hubert
A1 F. Aubourg
A1 B. Fauroux
A1 L. Trinquart
A1 I. Sermet
A1 G. Lenoir
A1 A. Clément
A1 A. T. Dinh-Xuan
A1 B. Louis
A1 B. Mahut
A1 C. Delclaux
YR 2009
UL http://erj.ersjournals.com/content/34/1/117.abstract
AB A reduction of exhaled nitric oxide (NO) fraction and endothelial-mediated dysfunction have been reported in cystic fibrosis (CF). The aims of the present study were to search for relationships between flow-independent NO exchange parameters (bronchial NO flux (J′aw,NO) and alveolar NO concentration (CA,NO)) and lung function tests characterising airflow limitation and pulmonary vascular bed (capillary blood volume and physiological dead space/tidal volume (VD/VT) ratio on exercise). In total, 34 patients (16 children, 18 adults) with CF, without resting pulmonary hypertension, underwent spirometry, exhaled NO measurement (multiple constant flow analytical method), gas transfer assessment (carbon monoxide and NO, allowing the calculation of capillary volume and membrane conductance) and a graded exercise test with oxygen uptake (V′O2), carbon dioxide production (V′CO2) and arterial blood gas evaluations. Both J′aw,NO and CA,NO correlated positively with airflow limitation. CA,NO correlated positively with capillary/alveolar volume. During exercise, criteria of mild pulmonary vascular disease were evidenced in some patients that participated in exercise limitation (negative correlation between physiological VD/VT and peak V′O2). CA,NO at rest correlated positively with these parameters of wasted ventilation during exercise (physiological VD/VT, minute ventilation (V′E)/V′CO2 at ventilatory threshold and V′E/V′CO2 slope). Flow-independent exhaled NO parameters are linked to airway and early vascular diseases in patients with CF.