PT  - JOURNAL ARTICLE
AU  - W. Hoefsloot
AU  - J. van Ingen
AU  - W. C. M. de Lange
AU  - P. N. R. Dekhuijzen
AU  - M. J. Boeree
AU  - D. van Soolingen
TI  - Clinical relevance of <em>Mycobacterium malmoense</em> isolation in the Netherlands
AID  - 10.1183/09031936.00039009
DP  - 2009 Oct 01
TA  - European Respiratory Journal
PG  - 926--931
VI  - 34
IP  - 4
4099  - http://erj.ersjournals.com/content/34/4/926.short
4100  - http://erj.ersjournals.com/content/34/4/926.full
SO  - Eur Respir J2009 Oct 01; 34
AB  - Uncertainty exists about the clinical relevance of Mycobacterium malmoense isolation, especially in pulmonary samples. We therefore determined clinical relevance, treatment and outcome of M. malmoense isolation in the Netherlands. A retrospective medical file study was conducted for all patients in the Netherlands from whom Mycobacterium malmoense had been isolated between January 2002 and January 2006. Diagnostic criteria for nontuberculous mycobacterial (NTM) disease published by the American Thoracic Society (ATS) were used to determine clinical relevance. Treatment was compared with guidelines published by the British Thoracic Society. In total, 51 patients were found from whom M. malmoense was isolated. Of these, 40 (78%) patients had pulmonary isolates and 32 (80%) of them met the ATS diagnostic criteria. Cavitary disease was most common (n = 28; 88%). Patients with pulmonary disease were mostly males, with an average age of 56 yrs and pre-existing chronic obstructive pulmonary disease. Cervical lymphadenitis was the most common extrapulmonary disease type. Adherence to treatment guidelines was poor. A good clinical response to treatment was observed in 70% and 73% of patients treated for pulmonary and extrapulmonary disease, respectively. In conclusion, M. malmoense is a clinically highly relevant NTM in the Netherlands causing serious pulmonary morbidity. Adherence to treatment guidelines is not satisfactory.